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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TGFB1I1 All Species: 28.79
Human Site: S403 Identified Species: 57.58
UniProt: O43294 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43294 NP_001035919.1 461 49814 S403 H F H A R R G S L C A T C G L
Chimpanzee Pan troglodytes XP_001159426 434 46626 A379 A R R G S L C A T C G L P V T
Rhesus Macaque Macaca mulatta XP_001113103 461 49794 S403 H F H A R R G S L C A T C G L
Dog Lupus familis XP_547052 461 49726 S403 H F H A R R G S L C A T C G L
Cat Felis silvestris
Mouse Mus musculus Q62219 461 50082 S403 H F H A Q R G S L C A T C G L
Rat Rattus norvegicus Q99PD6 461 50104 S403 H F H A Q R G S L C A T C G L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514315 225 25219 A170 A R R G S L C A A C G L P V T
Chicken Gallus gallus P49024 559 61224 S501 H Y H E R R G S L C S G C Q K
Frog Xenopus laevis Q2TCH4 506 55983 S448 H Y H S R R G S L C A G C E Q
Zebra Danio Brachydanio rerio Q6P7E4 419 45574 G364 M F G T K C H G C D F K I D A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_724183 557 61985 S499 H Y H A K R G S L C A G C S K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09476 413 46434 G358 S I C S Q C R G A I N G R C V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.1 99.5 93.2 N.A. 91.3 91.5 N.A. 45.3 43.4 43 22.7 N.A. 40.5 N.A. 36 N.A.
Protein Similarity: 100 94.1 99.5 95 N.A. 93 92.8 N.A. 47 55.9 56.7 34 N.A. 55.4 N.A. 51.8 N.A.
P-Site Identity: 100 6.6 100 100 N.A. 93.3 93.3 N.A. 6.6 60 66.6 6.6 N.A. 66.6 N.A. 0 N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. 13.3 73.3 80 13.3 N.A. 80 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 50 0 0 0 17 17 0 59 0 0 0 9 % A
% Cys: 0 0 9 0 0 17 17 0 9 84 0 0 67 9 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 9 0 0 0 9 0 % D
% Glu: 0 0 0 9 0 0 0 0 0 0 0 0 0 9 0 % E
% Phe: 0 50 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 0 0 9 17 0 0 67 17 0 0 17 34 0 42 0 % G
% His: 67 0 67 0 0 0 9 0 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 0 9 0 0 9 0 0 % I
% Lys: 0 0 0 0 17 0 0 0 0 0 0 9 0 0 17 % K
% Leu: 0 0 0 0 0 17 0 0 67 0 0 17 0 0 42 % L
% Met: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 % P
% Gln: 0 0 0 0 25 0 0 0 0 0 0 0 0 9 9 % Q
% Arg: 0 17 17 0 42 67 9 0 0 0 0 0 9 0 0 % R
% Ser: 9 0 0 17 17 0 0 67 0 0 9 0 0 9 0 % S
% Thr: 0 0 0 9 0 0 0 0 9 0 0 42 0 0 17 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 17 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 25 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _